VTPP Faculty Member - FRIEDHELM SCHROEDER, Ph.D.

FRIEDHELM SCHROEDER, Ph.D.

Professor

Email: fschroeder@cvm.tamu.edu

EDUCATION:

B.S., University of Pittsburgh
Ph.D., Biochemistry, Michigan State University
Postdoctoral Dept. of Biological Chemistry, Washington University Medical School

PREVIOUS EMPLOYMENT:

Associate Professor of Pharmacology, University of Missouri School of Medicine
Visiting Associate Professor of Biochemistry, University of Virginia
Associate Professor of Pharmacology & Medicinal Chemistry and Pharmacology & Cell Biophysics, University of Cincinnati Medical Center
Professor of Pharmacology & Medicinal Chemistry and Pharmacology & Cell Biophysics, University of Cincinnati Medical Center
Professor of Physiology and Pharmacology, Texas A&M University

HONORS:

Phillips Medalist in Chemistry
Phi Eta Sigma
Phi Beta Kappa
National Science Foundation Graduate Fellowship
Sigma Xi
American Cancer Society Postdoctoral Fellowship
Outstanding Researcher Award
John A. Boezi Memorial Alumnus Award

FUNDED RESEARCH (Direct Costs last 3 years):

Fatty Acid Binding Protein-Ligand Specificity (NIH $1,015,750).
Asymmetric Distribution of Cholesterol in Membranes (NIH $482,599).
Asymmetric Distribution of Cholesterol in Membranes-Supplement (NIH $112,462).

PROFESSIONAL SOCIETIES:

American Society for Pharmacology and Experimental Therapeutics
American Society for Biochemistry & Molecular Biology
American Chemical Society
Biophysical Society

EDITORIAL BOARDS AND REVIEW PANELS:

Lipids
Chemistry & Physics of Lipids
Protein Expression & Purification
Member, Metabolism Study Section, National Institutes of Health

SELECTED PUBLICATIONS (last 3 years):

Murphy E, Edmondson R, Russell D, Colles S, Schroeder F: Isolation & characterization of 2 distinct forms of liver fatty acid binding protein from the rat. Biochim.Biophys.Acta 1436:413-425, 1999.
Pu L, Annan RS, Carr SA, Frolov A, Wood WG, Spener F, Schroeder F: Isolation and Identification of a Native Fatty Acid Binding Protein from Mouse Brain. Lipids 34:363-373, 1999.
Chao H, Billheimer JT, Kier AB, Schroeder F: A microsomal long chain fatty acyl CoA transacylation: Differential effect of sterol carrier protein-2. Biochim. Biophys.Acta 1439:371-383, 1999.
Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F: Expression of fatty acid binding proteins is altered in aged mouse brain. Mol.Cell.Biochem. 198:69-78, 1999.
Wood WG, Schroeder F, Avdulov NA, Chochina SV, Igbavboa U: Recent advances in brain cholesterol dynamics: transport, domains, and Alzheimer’s disease. Lipids 34:225-234, 1999.
Avdulov NA, Chochina SV, Igbavboa U, Warden CS, Schroeder F, Wood WG: Lipid binding to sterol carrier protein-2 is inhibited by ethanol. Bichim.Biophys.Acta 1437:37-45, 1999.
Atshaves B, Petrescu A, Starodub O, Roths J, Kier A, Schroeder F: Expression and intracellular processing of the 58 kDa SCP-x/3-oxoacyl-CoA thiolase in transfected mouse L-cells. J. Lipid Research 40:610-622, 1999.
McArthur MJ, Atshaves BP, Frolov A, Foxworth WD, Kier AB, Schroeder F: Cellular uptake and intracellular trafficking of long chain fatty acids. J. Lipid Research 40:1371-1383, 1999.
Huang H, Ball JM, Billheimer JT, Schroeder F: The sterol carrier protein-2 amino terminus: a membrane interaction domain. Biochemistry 38:13231-13234, 1999.
Huang H, Ball JM, Billheimer JT, Schroeder F: Interaction of the sterol carrier protein-2 amino terminus: role of membrane curvature. Biochem. J. 344:593-603, 1999.
Stolowich N, Frolov A, Petrescu AD, Scott AI, Billheimer JT, Schroeder F: Holo-sterol carrier protein-2: ¹³C NMR investigation of cholesterol and fatty acid binding sites. J. Biol. Chem. 274:35425-35433, 1999.
Jolly C, Wilton D, Schroeder F: Microsomal fatty acyl CoA transacylation & hydrolysis:fatty acyl CoA species dependent modulation by liver fatty acyl CoA binding proteins. Biochim. Biophys. Acta 1483:185-197, 2000.
Jolly CA, Chao H, Kier AB, Billheimer JT, Schroeder F. Sterol carrier protein-2 suppresses microsomal acyl-CoA hydrolysis. Mol.Cell.Biochem. 205:83-90, 2000.
Gallegos AM, Schoer JK, Starodub O, Kier AB, Billheimer JT, Schroeder F: A potential role for sterol carrier protein-2 in cholesterol transfer to mitochondria. Chem. Phys. Lip. 105:9-29, 2000.
Murphy EJ, Stiles T, Schroeder F: Sterol carrier protein-2 expression alters phospholipid content and fatty acyl composition in L-cell fibroblasts. J. Lipid Research 41:788-796, 2000.
Frolov A, Petrescu A, Atshaves B, So P, Gratton E., Serrero G, Schroeder F: HDL-mediated cholesterol uptake and targeting to lipid droplets in intact L-cell fibroblasts. J. Biol. Chem. 275:12769-12780, 2000.
Schoer JK, Gallegos AM, McIntosh AL, Starodub O, Kier AB, Billheimer JT, Schroeder F: Lysosomal membrane cholesterol dynamics. Biochemistry 39:7662-7677, 2000.
Atshaves BP, Starodub O, Roths JB, Kier AB, Schroeder F: Sterol carrier protein-2 alters high density lipoprotein mediated cholesterol efflux. J. Biol. Chem. Web version: 10.1074/JBC.M0034342000, 2000.
Schroeder F, Frolov A, Starodub O, Atshaves BP, Russell W, Petrescu A, Huang H, Gallegos A, McIntosh A, Tahotna D, Russell D, Billheimer J, Baum C, Kier AB: Pro-sterol carrier protein-2: role of the N-terminal presequence in structure, function, and peroxisomal targeting. J. Biol. Chem. 275:25547-25555, 2000.
Starodub O, Atshaves BP, Schoer J, Roths JB, Kier AB, Schroeder F: Sterol carrier protein-2 immunocolocalization in endoplasmic reticululm and stimulation of phospholipid formation. Am.J.Physiol., In press, 2000.