VTPP Faculty Member - GLEN A. LAINE, Ph.D.

GLEN A. LAINE

Wiseman-Lewie-Worth Chair in Cardiology

Director
Michael E. DeBakey Institute for
Comparative Cardiovascular Science
and Biomedical Devices

Professor and Head,
Dept. of Veterinary Physiology & Pharmacology

Email: glaine@tamu.edu

EDUCATION:

B.S., Microbiology, University of Louisiana

M.S., Physics, University of Louisiana

Ph.D., Physiology and Biophysics, Texas A&M University, College of Medicine

Post Doctoral Fellow in Biophysics of Microvascular Transport, Microcirculation Research Institute

Research Fellow, Critical Care Medicine, Herman Hospital - UT Medical School - Houston

HONORS:

Distinguished Achievement Award in Research, Texas A&M University
Director, Center for Microvascular and Lymphatic Studies Texas Medical Center
Fellow, Cardiovascular Section, American Physiological Society
Coordinator of Research, Halboughty Endowment for Cardiovascular Science, Texas A&M
Upjohn Cardiovascular Investigator Award, International Society for Heart Research
Lamport Microvascular Investigator Award
Established Investigator of the American Heart Association

FUNDED RESEARCH (last 5 years):

Deutsche Forschungsgemeinschaft (Regents and Halboughty Fellowships $350,000)
Continuous endotracheal tube cleaning device. (Advance Technology Program $226,111)
Basic and Clinical Implications of Myocardial Edema (UT Medical Practice Plan Research Award $500,000)
NASA-National Space Biomedical Research Institute, Johnson Space Center. Consortium ($175,000)
Basic Determinants of Lymph Flow in Edema. (NIH-NHLBI Research Grant $776,583)
PMN Adherence Reactions: Role in Cardiopulmonary Bypass. NIH-NHLBI Research Grant, Co-Investigator ($950,000)
Reducing Morbidity and Mortality in patients with Cardiovascular Disease DHHS-Centers for Disease Control CCU 620069, Principal Investigator ($1,000,000)
Anti-edema mechanisms: Nitric oxide and thromboxane in the regulation of lymphatic function. Advanced Research Program, Co-Investigator ($131,125)

SELECTED RESEARCH PUBLICATIONS (last 3 years):

Davis, K., Mehlhorn, U., Schertel, E., Geissler, H., Laine, G.A., and Allen, S.: Variation in tau, the time constant for isovolumic relaxation, along the left ventricular base-to-apex axis. Basic Research in Cardiology 94(1):41-48, 1999.

Geissler, H. J., Davis, K. L., Melhorne, U., Laine, G. A., and Allen, S. J.: Contamination of Lymph from the major prenodal cardiac lymphatic in dogs. Am. J. Physiol. 276(45):1795-1800, 1999.

Geissler, H. J., Davis, K. L., Laine, G. A., and Allen, S. J.: High dose beta-blockade as an alternative to warm blood cardioplegia in acute myocardial ischemia. Cardiothoracic Surgery 17:63-70, 2000.

Davis, K. L., Geissler, H.J., Allen, S.J., and Laine, G.A.: The effects of myocardial edema on the development of myocardial interstitial fibrosis. Microcirculation. 7 (4): 269-280, 2000.

Stewart, R.H., Allen, S.J., and Laine, G.A.: Protein washdown as a defense mechanism against myocardial edema. Am. J. Physiol. 279:H1864-H1868, 2000.

Stewart, R. and Laine, G.A.: Flow in lymphatic networks: Interaction between hepatic and intestinal lymph vessels. Microcirculation. 8:221-227, 2001.

Mehlhorn, U., Geissler, H., Laine, G.A. and Allen S.J.: Role of the cardiac lymph system in myocardial fluid balance. Cardio-Thoracic Surgery. 20:420-425, 2001.

Sauer, H. Allen, S., Cox, C. Jr., and Laine, G.A.: Effect of Sialyl Lewis^x selection blockade on myocardial stunning after cardioplegic arrest and reperfusion. Heart Surgery. 4(3): 216-222, 2001.

Geissler, H., David, K., Buja, M., Laine, G.A., Brennan, M., Mehlhorn, U., and Allen, S.: Esmolol and cardiopulmonary bypass during reperfusion reduce infarct size in a dog model of myocardial ischemia and reperfusion. Annals of Thoracic Surgery 72: 1964-1969, 2001.

Geissler, H., Mehlhorn, U., Laine, G.A. and Allen, S.J.: The effect of cardiopulmonary lymphatic obstruction on heart and lung function. Cardio-Thoracic Cardiovascular Surgery. 49:384-385, 2001.

Mehlhorn, U., Geissler, H., Laine, G.A. and Allen, S.J.: Myocardial fluid balance. Cardio-Thoracic Surgery. 20:1220-1230, 2001.

Cox, C., Sauer, H., Allen, S., Buja, L., and Laine,G.A.:Sodium/hydrogen-exchanger inhibition during cardioplegic arrest and cardiopulmonary bypass. Thoracic and Cardiovascular Surgery (In Press), 2001.

Cox, C.S., Allen, S.J., Sauer, H. and Laine, G.A.: Improved myocardial function using a Na⁺/H⁺ -exchanger inhibitor during cardioplegic arrest and cardiopulmonary bypass. Chest (In press), 2002.