DEBORAH T. KOCHEVAR, D.V.M., Ph.D.

diplomate ACVCP

Professor Email: dkochevar@cvm.tamu.edu

EDUCATION:

• B.A., Rice University, 1978
• D.V.M., Texas A&M University, 1981
• Ph.D., Southwestern Graduate School of Biomedical Sciences, the University of Texas Health Science Center, Dallas, 1987

• Kochevar, D.T. and Anderson, R.G.W. Purified crystalloid endoplasmic reticulum from UT-1 cells contains multiple proteins in addition to 3-hydroxy-3-methylglutaryl coenzyme A reductase. J. Biological Chemistry 262: 10321-10326, 1987.
• Kochevar, D.T., Brown, S.A., and Booth, D.M. Initiatives in Clinical Research. JAVMA 197: 580-583, 1990.
• Kochevar, D.T., Kochevar, J. and Garrett, L. Low level amplification of c-sis and c-myc in a spontaneous osteosarcoma model. Cancer Letters 53: 213-222, 1990.
• Kochevar, Deborah T., Butler, M., and Cooper, J. Mammalian heat shock proteins: An overview with a systems approach. Toxicology Letters. 56: 243-267. 1990.
• Alden, C.L., Andrews, E.J., Bowen, J.M., Fletcher, O.J., Fulton, R.W., Kochevar, D., Mather, E.C., Perryman, L.E., Schmitz, J.A., Tennant, B.C. Veterinary medical research: a national resource. J Am Vet Med Assoc 205: 1689 – 1693, 1994.
• Aucoin, M.M., Barhoumi,R., Kochevar, D.T. , Granger, H.J. and Burghardt, R.C. Oxidative injury of coronary venular endothelial cells depletes intracellular glutathione and induces HSP70. Am.J. Physiol. 268 (Heart Circ.Physiol.37): H1651-H1658, 1995.
• Mitchell, D.M. and Kochevar, D.T. The effect of sterols and brefeldin A on protein degradation in UT-1 cells. Exp. Cell Res. 216: 135-142, 1995.
• Kochevar, D.T., Middendorf, D., Mealey, K., Meyers, R., Rogers, K., Barton, C., Alberts, B and Habron, J. Pharmacokinetics and hematologic effects of a single, intravenous dose of mitoxantrone in cats. J.Vet.Pharm.Therapeutics 18: 471-475, 1995.
• Kochevar, D.T. and Mealey, K. Antineoplastic Chemotherapy. Veterinary Medicine 92:336-349, 1997.
• Mealy, K., Barhoumi, R., Rogers, K.and Kochevar, D. Doxorubicin-induced expression of P-glycoprotein in a canine osteosarcoma cell line. Cancer Letters 126: 187 – 192, 1998.
• Mealey, K.L, Barhoumi, R., Burghardt, R.C., McIntyre, B.S., Sylvester, P.W., Hosick, H., Kochevar, D.T. Immunosuppressant inhibition of P-glycoprotein function is independent of drug-induced suppression of peptide-prolyl isomerase and calcineurin activity. Cancer Chemotherapy and Pharmacology 44:152-158, 1999.
• Johnson, K.A., Hart, R.C., Chu, Q., Kochevar, D., Hulse, D. Synovial fluid chondroitin sulfate epitopes 3B3 and 7D4 concentrations after intra-articular and extracapsular cranial cruciate ligament reconstruction in dogs. American Journal Veterinary Research 62(4):581-587, 2001.
• Johnson, K.A., Hulse, D., Hart., R.C., Kochevar, D., Chu, Q. Effect of an orally administered mixture of chondroitin sulfate, glucosamine hydrochloride and manganese ascorbate on synovial fluid chondroitin sulfate 3B3 and 7D4 epitope in a canine cruciate ligament transection model of osteoarthritis. Osteoarthritis and Cartilage 9:1, 14-21, 2001.
• Mealey, K.L., Barhoumi, R., Burghardt, R.C., Safe, S., Kochevar, D. Doxycycline induces expression of P glycoprotein in MCF7 breast carcinoma cells. Antimicrob Agents Chemother 46:755-761, 2002.
• Botos, J., Smith, R., Kochevar, D. Retinoblastoma function is a better indicator of cellular phenotype in cultured breast adenocarcinoma cells than retinoblastoma expression. Exp Biol Med 227:354-362, 2002.
• Botos, J., Barhoumi, R., Burghardt, R., Kochevar, D. Rb localization and phosphorylation kinetics correlate with the cellular phenotype of cultured breast adenocarcinoma cells. In Vitro Cellular Devel Biol (Animal) 38: (pages), in press 2002.

Dept. Info | Phys., Pharm., Res. & Grad. Program | Toxicology Res. & Grad. Program |
Post-Doc Teaching Program | Faculty | Courses | Services | Links |