CUIHUA ZHANG

Assistant Professor Email: czhang@cvm.tamu.edu

EDUCATION:

M.D., Jin Zhou Medical College, Liao Ning, China, 1985

Ph.D., Peking Union Medical College, Beijing, China, 1995

Postdoctoral Training: Department of Physiology, Texas A&M University, 1998

EMPLOYMENT:

Teaching Assistant, Department of Physiology, Jin Zhou Medical College

Assistant Research Scientist, Department’s of Medical Physiology, College of Medicine, Texas A&M University

Assistant Professor, Departments of Anesthesiology, Surgery and Physiology, LSU Health Sciences Center, School of Medicine, New Orleans, LA

Assistant Professor, Department of Veterinary Physiology & Pharmacology, College of Veterinary Medicine, Texas A&M University, College Station, Texas

HONORS:

Conselho Nacional de Desenvolvimento Cientifico and Tecnologico (CNPq) Fellowship, Brazilian Government

The Microcirculatory Society Travel Award for Outstanding Young Investigators

American Physiology Society CV Section Young Investigator Award

Editorial Board: AJP-Heart and Circulatory Physiology

Study Section: Member of AHA Peer Review Committee

Journal Reviewer: 1. Circulation; 2. Circulation Research; 3. American Journal of Physiology; 4. Basic Research in Cardiology College; 5. Journal of the American College of Cardiology;  6. Arteriosclerosis Thrombosis and Vascular Biology; 7. Trends in Pharmacological Sciences.

FUNDED RESEARCH SUPPORT:

Mechanisms of Reperfusion-Induced Endothelial Injury (Principal Investigator). Atorvastatin Research Award ARA, Pfizer: $150,000.

Mechanisms of Reperfusion-Induced Endothelial Injury (Principal Investigator).  American Heart Association (AHA); Southeast Affiliate Grant-In-Aid. $154,000.

Role of Inflammation on Endothelial Reperfusion Injury. NIH COBRE grant (Project Leader), $220,000.       

Role of TNF alpha in Endothelial Dysfunction in the Metabolic Syndrome and in Diabetes (Principal Investigator). Scientist Development Grant (SDG), American Heart Association (AHA); $260,000.
Mechanisms of Reperfusion-induced Endothelial Injury (Principal Investigator). National Institutes of Health; Heart, Lung, and Blood Institute. NIH RO1: $1,808,540.

PROFESSIONAL SOCIETIES:

American Heart Association, Basic Science Council

American Physiological Society

Microcirculatory Society

SELECTED RESEARCH PUBLICATIONS:

1. Cuihua Zhang, X. Wang and Y. Zheng. The relation of endothelium-derived factors and hypertension. Overseas Medicine. 14(94): 224-226;1994.
2. Cuihua Zhang, X. Wang and Y. Zheng.  Decreased endothelium-dependent relaxation and the mechanism in vessel of SHRsp. Chinese Circulation Journal. 9(2):106-107,1994.
3. Y. Zheng, Cuihua Zhang. The effects of L-NNA and reduced hemoglobin on endothelium-dependent relaxation of mesenteric artery in SHRsp. Acta Physiologica Sinica. 6(6):568-574, 1994.
4. Cuihua Zhang, X. Wang and Y. Zheng. Endothelium-derived hyperpolarizing factor. Overseas Medicine. 14(2):119;1994.
5. Cuihua  Zhang,  X. Wang  and Y. Zheng. L-arginine relaxation of mesenteric artery in SHRsp and WKY. Chinese Joural of Hypertension. 2(1):32-34,1994.
6. Cuihua  Zhang, X. Wang and Y. Zheng. Effects of methylene blue and  indomethacin on the attenuation of endothelium-dependent relaxation in visceral vessel of SHR Rats. Basic Medical Sciences and Clinics. 14(4):41-45,1994.
7.Cuihua Zhang, X. Wang and Y. Zheng. Endothelium-derived relaxation factor and nitric oxide. Progress In Physiological Sciences. 26(2):172-174;1995.
8.  L. Tao and Cuihua Zhang. Endothelium derived contracting factor. The Journal of Jinzhou Medical College. 26(9):132-134;1996.
9. W. Hu, Cuihua Zhang, H. Yang, Y. Zheng, N. Liu, X. Sun and M. Ren. Dualistic effect of dynorphin on high potassium-induced increase of intracellular free calcium concentration in cultured rat spinal neurons. Chinese Journal of Pharmacology and Toxicology. 12(1):32-35, 1998.
10. W. Hu, Cuihua Zhang, Y. Zheng, N. Liu, X. Sun, J Jen, and M. Ren. Mechanism of dynorphin-induced dualistic effect on free intracellular Ca2+ concentration in cultured rat spinal neurons. European Journal of Pharmacology. 342(2-3):325-332, 1998.
11. Cuihua Zhang, LGH. Bonagamba and BH. Machado. Blockade of NK-1 receptors in the nucleus tractus solitarii of awake rats produced no effect on the cardiovascular responses to chemoreflex activation. Brazilian Journal of Medical and Biological Research, 33(11) 1379-1385, November, 2000.
12. Cuihua  Zhang, TW. Hein and L. Kuo. Transmural difference in coronary arteriolar dilation to adenosine: effect of luminal pressure and KATP channels. American Journal of Physiology-Heart and Circulatory Physiology. 279(6): H2612-2620, 2000.
13. RJ. Rivers, TW. Hein, Cuihua  Zhang and L. Kuo. Activation of Barium-Sensitive Inward Rectifier Potassium Channels Mediates Conducted Remote Dilation of Coronary Arterioles. Circulation. 104:1749-1753, 2001.
14. KT. Huang, TH. Han, DR. Hyduke, MW. Vaughn, Herle Van, TW. Hein, Cuihua Zhang, L. Kuo, and JC. Liao. Modulation of nitric oxide biovailability by Erythrocytes. Proc. Natl. Acad. Sci. USA. 98:11771-11776, 2001.
15. Cuihua Zhang, TW. Hein, W. Wang and L. Kuo. Constitutive expression of arginase in microvascular endothelial cells counteracts nitric oxide-mediated vasodilatory function. FASEB J. 15(7):1264-6, 2001.
16. Cuihua  Zhang, TW. Hein,W. Wang and L. Kuo, Divergent roles of angiotensin II AT1 and AT2 receptors in modulating coronary microvascular function. Circulation  Research.  92:322-329, 2003.
17. Travis W. Hein, Cuihua  Zhang (Co-first author), Wei. Wang, Chong-I. Chang, Naris Chengchaisri and Lih Kuo. Ischemia-reperfusion selectively impairs nitric oxide-mediated dilation in coronary arterioles: counteracting role of arginase. The FASEB Journal express article. FASEB J. 2003.17(15):2328-30.
Published online October 16, 2003. (http://www.fasebj.org/cgi/reprint/03-0115fjev1)
18. Travis W. Hein, Cuihua Zhang (Co-first author), Wei Wang, Lih Kuo. Transmural difference in coronary arteriolar dilation to ß-adrenergic receptor activation: role of ß2-adrenergic receptors and KATP channels. Circulation. 110(17):2708-12, 2004.
19. Cuihua Zhang,Travis W. Hein, Wei Wang, Matthew W. Miller, Theresa W. Fossum, Michelle M. McDonald, Jay D. Humphrey, Lih Kuo: Upregulation of Vascular Arginase in Hypertension Decreases Nitric Oxide-Mediated Dilation of Coronary Arterioles. Hypertension. 44:1-9, 2004.
20. Daphne Merkus, Anna Brzezinska, Cuihua Zhang, Suichi Sato and William M. Chilian. Cardiac myocytes control release of endothelin-1 in the coronary vasculature. American Journal of Physiology-Heart and Circulatory Physiology.  288:H2088-2092, 2005.
21. Cuihua Zhang, Srinath Setty, Lih Kuo, Johnathan D. Tune. Coronary arteriolar constriction to Angiotensin II is augmented in the prediabetic metabolic syndrome via activation of AT1 receptors. American Journal of Physiology-Heart and Circulatory Physiology. 288:H2154-H2162, 2005.
22. Knudson JD, Dincer UD, Cuihua Zhang, Swafford AN Jr, Koshida R, Picchi A, Focardi M, Dick GM, Tune JD. Leptin receptors are expressed in coronary arteries, and hyperleptinemia causes significant coronary endothelial dysfunction. Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H48-56.
23. Koshida R, Rocic P, Saito S, Kiyooka T, Cuihua Zhang, Chilian WM. Role of focal adhesion kinase in flow-induced dilation of coronary arterioles. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2548-53.
24. Merkus D, Brzezinska AK, Cuihua Zhang, Saito S, Chilian WM. Cardiac myocytes control release of endothelin-1 in coronary vasculature. Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2088-92.
25. Zhang C, Hein TW, Wang W, Ren Y, Shipley RD, Kuo L. Activation of JNK and Xanthine Oxidase by TNF-a Impairs Nitric Oxide-Mediated Dilation of Coronary Arterioles. Journal of Molecular and Cellular Cardiology. 2006 Feb;40(2):247-257.
26. Cuihua Zhang (Correspondence Author), Xiangbin Xu, Barry J. Potter, Wei Wang, Lih Kuo, Lloyd Michael, Gregory J. Bagby, and William M. Chilian. TNF-alpha Contributes to Endothelial Dysfunction in Ischemia/Reperfusion Injury. Arteriosclerosis, Thrombosis and Vascular Biology. 2006; 26:475-480.
 27. Andrea Picchi, Xue Gao, Marta Focardi, Souad Belmadani, Wei Wang, Eric T Guilbeau, William M Chilian and Cuihua Zhang (Correspondence Author). TNF lpha Induces Endothelial Dysfunction in the Prediabetic Metabolic Syndrome. Circulation Research. 2006, 99:69-77.
28. Alan D. Kaye, MD, Jason M. Hoover, Syed R. Baber, Ikhlass N. Ibrahim, James Phelps, Amir Baluch, Cuihua Zhang and Aaron Fields. Analysis of the effects of fentanyl in the feline pulmonary vascular bed.  (In Press. 2006)
29. Alan D. Kaye, Amir Baluch, James Phelps, Syed R. Baber, Ikhlass N. Ibrahim, Jason M. Hoover, Cuihua Zhang and Aaron Fields. The role of remifentanil in the pulmonary vascular bed of the cat. (In Press. Anesthesia and Analgesia. January, 2006)

30. Alan D. Kaye, James Phelps, Amir Baluch, Ikhlass N. Ibrahim, Jason M. Hoover, Syed R. Baber, Christopher Armstrong, Cuihua Zhang and Aaron Fields. The effects of suffentanil in the feline pulmonary vascular bed. (In Press. 2006).