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Abstract

Pharmacokinetics of carprofen in donkeys and horses

Melissa L. Burchfield, Nora S. Matthews, DVM; Kenneth E. Peck, MS; T.S. Taylor, DVM

Objective-To compare plasma disposition of R and L enatiomers of carprofen after IV administration of a bolus dose in donkeys and horses.

Animals:-Five clinically normal donkeys and three clinically normal horses.

Procedure-Blood samples were collected at time 0 (before), at 5, 10, 15, 20, 30 and 45 minutes, and at 1, 1.5, 2, 2.5, 3, 4, 5, 6, 8, 10, 24, 28, 32, and 48 hours after IV administration of a bolus dose of carprofen (0.7 mg/kg of body weight).  Plasma was analyzed in triplicate by the use of high performance liquid chromatography for determination of carprofen concentrations.  The plasma  concentration-time curve for each donkey and horse was analyzed separately to estimate non-compartmental pharmacokinetic variables.

Results- Pending completion of sample analysis

Conclusion and Clinical Relevance- Pending completion of sample analysis