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Associate Professor, Veterinary Anatomy & Public Health,
College of Veterinary Medicine
, Texas A&M University
Associate Professor, Animal Science,
College of Agriculture and Life Sciences
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Implantation/Trophoblast
Biology/ Early Pregnancy
Growth Factors/Matrix
Proteins/
Cell Signaling
In vitro Models
Domestic Animal Models
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Education
The Pennsylvania State University, State College, PA, B.S. (Animal
Science) B.S., 1980
Purdue University, West Lafayette, IN, D.V.M., 1984
Purdue University, West Lafayette, IN, Ph.D. (Veterinary Anatomy),
1991
Professional Experience
Clinical:
1984 - 1985 Mixed animal practitioner, Mostrom Animal Clinic,
Manly, Iowa
Academic:
1985-1987 Visiting Instructor, Department of Veterinary
Anatomy, Purdue University
1987-1991 Graduate Instructor, Department
of Veterinary Anatomy, Purdue University
1991-1997 Assistant Professor, Department
of Veterinary Anatomy and Public Health,
Texas A&M University, College Station, Texas.
Joint appointment: Department
of Animal Science, Texas A&M University
1997- Associate
Professor, Department of Veterinary Anatomy and Public Health,
Texas A&M University
Joint appointment: Department of Animal
Science, Texas A&M University.
Membership on Texas A&M University Faculties
1991 - Member,
Graduate Faculty
1992 - 1999 Member, Center for Animal Biotechnology,
Institute for Biosciences and Technology
1995 - Member,
Faculty of Reproductive Biology
1998 - Member,
Faculty of Toxicology
2000- Member,
Center for Animal Biotechnology and Genomics, Institute for Biosciences
and Technology
1999 -2001 Vice Chair (1999-2001), Chair (2001)
Intercollegiate
Faculty of Reproductive Biology
Societies, Honors, and Professional Activities
Professional Societies
Member of : American Association for the Advancement of Science, American
Association of Anatomists, American Association of Veterinary Anatomists
American Veterinary Medical Association, Society for In Vitro Biology,
Society for the Study
of Reproduction
Teaching Awards and Honors
Center For Teaching Excellence (CTE) Scholar for the College
of Veterinary Medicine, Texas A&M University (1996-1997)
Texas A&M Association of Former Students College Level Distinguished
Teaching Award (1997)
Wiley Distinguished Teaching Professorship in Veterinary Medicine (1999-2002)
Texas A&M Association of Former Students Faculty Distinguished
Achievement Award in Teaching (2001)
Honor Societies: Alpha Zeta, Gamma
Sigma Delta, Phi Zeta, Phi Kappa Phi
Research
The laboratory is focused on understanding fundamental mechanisms associated
with successful implantation and establishment of pregnancy. Differentiation
of peri-implantation trophoblast and the integrated roles of growth factors,
steroid hormones, extracellular matrix proteins, and integrins in mediating
conceptus-maternal interactions during implantation are the major areas
of emphasis. The current focus of the lab is on the role of the beta transforming
growth factors (TGFßs) during implantation; in vitro and in vivo
porcine and ovine models are being utilized to determine expression and
functions of TGFß-associated molecules at the conceptus-maternal
interface.
Major Classroom Teaching Responsibilities
Veterinary Anatomy and Public Health (VAPH) 912, Gross Anatomy
II (Gross Anatomy of Large Domestic Species), Professor-In-Charge.
This is a required laboratory-based class for students in the first
year of the professional veterinary curriculum. The focus of the
class is on gross and topographical anatomy of domestic livestock (equine,
ruminant, porcine, and avian species), with emphasis on structures of
clinical relevance and integration of structure with function.
Recent Publications
Gupta A., Ing N.H., Bazer F.W., Bustamante
L.S., Jaeger L.A. 1998. Beta transforming growth factors (TGFßs)
at the porcine conceptus-maternal interface. Part I: Expression of TGFß1,
TGFß2, and TGFß3 messenger ribonucleic acids. Biology of Reproduction,
59:905-910.
Gupta A., Dekaney C.M., Bazer F.W, Madrigal M.M., Jaeger L.A.
1998. Beta transforming growth factors (TGFßs) at the porcine
conceptus-maternal interface. Part II: Uterine TGFß bioactivity
and expression of immunoreactive TGFßs (TGFß1, TGFß2,
and TGFß 3) and their receptors (Type I and Type II). Biology
of Reproduction, 59:911-917.
Wu G., Flynn N.E., Knabe D.A, Jaeger L.A. 2000. A cortisol
surge mediates the enhanced polyamine synthesis in porcine enterocytes
during weaning. American Journal of Physiology, 279:R554-559 .
Dekaney CM, Wu G, Jaeger LA. 2000. Regulation and function of
ornithine aminotransferase in animals. Trends in Comparative Biochemistry
and Physiology 6:175-183.
Dekaney CM, Wu G, Jaeger LA. 2001. Ornithine aminotransferase messenger
RNA expression and activity in fetal porcine small intestine.
Pediatric Research, 50:104-109.
Ka H, Jaeger LA, Johnson GA, Spencer TE, Bazer FW. 2001. Keratinocyte
growth factor is up-regulated by estrogen in the porcine uterine endometrium
and functions in trophectoderm cell proliferation and differentiation.
Endocrinology: 142:2303-2310.
Johnson GA, Bazer FW, Jaeger LA, Ka H, Garlow JE, Pfarrer C, Spencer
TE, and Burghardt RC (2001) Muc-1, integrin and osteopontin expression
during the implantation cascade in sheep. Biology of Reproduction 65:820-828.
Jaeger LA, Burghardt RC, Bazer FW, Johnson GA, Ka H, Garlow, JE.
2001. Functional analysis of autocrine and paracrine signalling
at the uterine-conceptus interface in pigs. J Repro Fertil Suppl 58:191-207.
Garlow JE, Ka H, Johnson GA, Burghardt RC, Jaeger LA, Bazer FW.
2002. Analysis of osteopontin at the maternal-placental interface
in pigs. Biology of Reproduction 66:718-725.
Burghardt RC, Johnson GA, Jaeger LA, Ka K, Garlow JE, Spencer E, Bazer
FW. Integrins and extracellular matrix proteins at the maternal-fetal
interface in domestic animals. Cells, Tissues, Organs (In
Press).
See PubMed for other publications
Book chapters (teaching related):
Jaeger LA, Kochevar D. Chapter 12. Teaching Large Classes in
Veterinary Medicine. In: Engaging Large Classes - Strategies and
Techniques for College Faculty. eds. C. Stanley, E. Porter. (In
press)
Reviewer Activity
Reviews for professional journals: Board of Scientific
Reviewers, American Journal of Veterinary Research (1994-1997); Editorial
Board member, Biology of Reproduction
(2000 -2003); Ad hoc reviewer: American Journal of Veterinary
Research, Journal of the American Veterinary Medical Association, Biology
of Reproduction , Journal of Nutrition, Reproduction.
Ad hoc grant review: USDA/NRICGP, Cellular Growth and
Developmental Biology of Animals; USDA/NRICGP, Enhancing Reproductive
Efficiency; USDA/NRICGP, Animal Reproduction; Binational Agricultural
Research and Development Fund
Comments to:
ljaeger@cvm.tamu.edu
Revised: June 16, 2002.
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