Important Landmarks in the history
of Foot and Mouth Disease
|
1546
|
Description
of the disease (Fracastorius) |
|
1897 |
Identification
of the causal agent (Loefiler & Frosch); First example of an
animal disease caused by a virus |
|
1920 |
|
|
1922-6
|
(Vallée &
Carré
1922;
Waldmann
& Trautwein 1926)
|
|
1925
|
First
vaccination against the disease (Vallée et al.) |
|
1930
|
Growth
of virus outside animal body (Hecke 1930, 193,) |
| 1947 | Growth of virus on large scale in tongue tissue fragments, making mass vaccination possible (Frenkel) |
|
1948
|
Recognition
of three serotypes from Southern Africa distinct from 0, A and
C
(see Brooksby 1958) |
|
1951
|
Use of suckling mouse as experimental animal (Skinner) |
|
1952
|
Mass
vaccination started in Holland |
|
1954
|
Recognition of 7th serotype, Asia 1 (Brooksby 1958). |
|
1958
|
Observation of virus in electron microscope (Bachrach & Breese) |
|
1958
|
Role
of 146S particle in immunization (Brown & Crick). Isolation of
infectious
ribonucleic acid from the virus (Brown et al.) |
| 1962 | Growth of virus in a cell line (Mowat & Chapman; Capstick et al.) |
|
1963 |
Purification
of the virus particle (Brown & Cartwright) |
| 1965 | Demonstration of recombination between virus strains (Pringle) |
|
1966
|
Viral polymerase recognized by serological methods (Cowan & Graves) |
|
1969 |
|
|
1969 |
|
|
1973 |
Demonstration
that a single isolated protein will evoke neutralizing antibody
(Laporte et
at.) |
|
1977 |
Biochemical
mapping of the virus genome (Sangar et al.) |
| 1981 | Expression in E. coli cells of the immunogenic protein (Kleid et al.) |
|
1982
|
Chemical
synthesis of a peptide which evokes protective response (Bittle
et at.;
Pfaff et
at.) |
|
1984
|
First
crystals
of the virus particle (Fox et at. 1987) |
|
1986 |
First complete nucleotide sequence of the virus
genome (Clarke & Carroll) |