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Autosomal Recessive Familial Nephropathy

We have identified the mutation that causes Autosomal Recessive Familial Nephropathy (ARFN) in the English Cocker Spaniel. ARFN is a juvenile onset renal disease homologous to Alport syndrome in humans. This type IV collagen disorder causes death in affected puppies 6 months to 2 years of age. Genetic testing for the mutation is available in the U.S. and Canada at Optigen. This work was carried out by Ashley Davidson with help from Rebecca Bell.

"Rigley"